The Institute for Vascular Signalling is a research institute that studies the biology of the vascular wall, heart and the factors that influence them during disease development. There is a particularly strong focus on the endothelial cells that are the inner most lining of the blood vessel and directly exposed to the flowing blood. We study substances generated by the endothelial cells themselves such as nitric oxide, hydrogen sulfide, mediators generated from polyunsaturated fatty acids and, more recently, microproteins. A further series of projects focus on the cardiovascular complications of diabetes in the heart as well as the impact of platelets, platelet-derived products and monocytes. All of the projects have a translational biomedicine emphasis with the aim of improving on current cardiovascular disease therapy.
Collaborative networks:
Projects housed at the Institute for Vascular Signalling belong to four different collaborative research centres (CRCs) including CRC 1531 Damage control by the stroma-vascular compartment, CRC 1039 Disease-relevant signal transduction by fatty acid derivatives and sphingolipids, CRC 1366 Vascular Control of Organ Function and CRC-TRR 267 Cardiovascular ncRNAs. The institute also belongs to the German Research Foundation funded Excellence Cluster Cardio Pulmonary Institute ( CPI) and the German Centre for Cardiovascular Research ( DZHK).
At the Institute for Vascular Signalling, Center for Molecular Medicine at the Faculty of Medicine, Goethe University, there is an open
Postdoc position (m/f/d)
(E13 TV-G-U)
to study the consequences of targeting the soluble epoxide hydrolase with proteolysis targeting chimeras (PROTACs) in vitro and in vivo. The position is available immediately and is funded for 2 years with the possibility of renewal. The pay scale is based on the job characteristics of the collective agreement applicable to Goethe University (TV-G-U). The position requires the following:
participation in a research project focusing on the consequences of targeting the soluble epoxide hydrolase in macrophages, cardiomyocytes, angiotensin II-induced hypertension and cardiac function
experience in cell isolation, confocal microscopy, and ideally in in vivo models
collection of experimental data, analysis and documentation of results and preparation of material for publication
Requirements:
a completed, very good PhD in biology, biotechnology, molecular medicine or an equivalent discipline
experience in cardiovascular biology/physiology and confocal microscopy
a FELASA B certificate
good self-organization and ability to work in a team
excellent written and spoken English
We offer:
a thematic high-level project in an internationally recognized group (www.ivs.uni-frankfurt.de) that is part of the DFG Cluster of Excellence \"CardioPulmonary Institute\" (www.cpi-online.de) and the German Center for Cardiovascular Research (www.dzhk.de)
rooms, housed in a research building with modern facilities and analysis possibilities from integrative physiology to mass spectrometry
